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Antimicrobial resistance and the environment: intervention strategies

Prof. Magdalena Popowska with collaborators

Antimicrobial resistance (ARM) has been recognized by the WHO as one of the greatest threats faced by the modern world. Addressing this issue requires an integrated “One Health” approach that combines human and animal health with taking care of the environment. Increasing urbanization and industrialization of agriculture contribute to the spread of antibiotic resistance genes (ARGs) and antibiotic-resistant bacteria (ARB), posing serious risks to public health. 

Research has identified key hotspots, such as biological wastewater treatment plants, soil, and natural fertilizers, as sites of accumulation and transfer of ARGs. Current wastewater treatment methods have been proven insufficient in fully eliminating ARB, leading to their release into aquatic environments. Studies have also evaluated the effectiveness of composting in reducing resistance genes and multidrug-resistant pathogens in livestock manure. The resulting natural fertilizer exhibited high quality and environmental safety.

Additionally, research has shown that biodiversity in soil and water limits the invasion of antibiotic-resistant bacteria, serving as a natural barrier to the spread of resistance. Maintaining high levels of biological diversity may be crucial in combating this global challenge.

MODERN APPLICATIONS:

The findings support the development of advanced wastewater treatment technologies, safe manure processing methods, and biodiversity conservation strategies to curb the spread of antimicrobial resistance.

FIGURE CAPTIONS:

Top: The One Health concept – a strategy to combat antimicrobial resistance.

Bottom: Pseudomonas bacteria.

RELATED PUBLICATIONS:

  1. Zalewska M, Błażejewska A, Gawor J, Adamska D, Goryca K, Szeląg M, Kalinowski P, Popowska M. (2024) The IncC and IncX1 resistance plasmids present in multi-drug resistant Escherichia coli strains isolated from poultry manure in Poland. Environ Sci Pollut Res Int 31:47727–47741. doi: 1007/s11356-024-34283-w
  2. Zalewska M, Błażejewska A, Gawor J, Adamska D, Goryca K, Szeląg M, Kalinowski P, Popowska M. (2024) A newly-identified IncY plasmid from multi-drug resistant Escherichia coli isolated from dairy cattle feces in Poland. Microbiol Spectr 12:e00877-24. doi: 1128/spectrum.00877-24
  3. Zalewska M, Błażejewska A, Szadziul M, Ciuchciński K, Popowska M. (2024) Effect of composting and storage on the microbiome and resistome of cattle manure from a commercial dairy farm in Poland. Environ Sci Pollut Res Int 31:30819–30835. doi: 1007/s11356-024-33276-z
  4. Klümper U et al. (2024) Environmental microbiome diversity and stability is a barrier to antimicrobial resistance gene accumulation. Commun Biol 7, 706. doi: 1038/s42003-024-06338-8
  5. Goryluk-Salmonowicz A, Myczka AW, Popowska M. (2024) Antibiotic- and metal-resistant endophytes inhabit Armeria maritima hyperaccumulator. Plant Soil 495, 57–76. doi: 1007/s11104-023-06320-z
  6. Zalewska M, Błażejewska A, Czapko A, Popowska M (2023) Pig manure treatment strategies for mitigating the spread of antibiotic resistance. Sci Rep 13:11999. doi: 1038/s41598-023-39204-4
  7. Goryluk-Salmonowicz A, Popowska M. (2022) Factors promoting and limiting antimicrobial resistance in the environment – Existing knowledge gaps. Front Microbiol 13:992268. doi: 3389/fmicb.2022.992268
  8. Błażejewska A, Zalewska M, Grudniak A, Popowska M. (2022) A Comprehensive Study of the Microbiome, Resistome, and Physical and Chemical Characteristics of Chicken Waste from Intensive Farms. Biomolecules 12:1132. doi: 3390/biom12081132
  9. Zalewska M, Błażejewska A, Czapko A, Popowska M. (2021) Antibiotics and antibiotic resistance genes in animal manure – consequences of its application in agriculture. Front Microbiol 12:640. doi: 3389/fmicb.2021.610656
  10. Anjum M et al. (2021) The potential of using E. coli as an indicator for the surveillance of antimicrobial resistance (AMR) in the environment. Curr Opin Microbiol 64:152-158. doi: 1016/j.mib.2021.09.011
  11. Marano RBM et al. (2020) A global multinational survey of cefotaxime-resistant coliforms in urban wastewater treatment plants. Environ Int 144:106035. doi: 1016/j.envint.2020.106035
  12. Piotrowska M, Dziewit L, Ostrowski R, Chmielowska C, Popowska M. (2020) Molecular Characterization and Comparative Genomics of IncQ-3 Plasmids Conferring Resistance to Various Antibiotics Isolated from a Wastewater Treatment Plant in Warsaw (Poland). Antibiotics 9:613. doi: 3390/antibiotics9090613
  13. Piotrowska M, Kowalska S, Popowska M. (2019) Diversity of β-lactam resistance genes in gram-negative rods isolated from a municipal wastewater treatment plant. Ann Microbiol 69:591–601. doi: 1007/s13213-019-01450-1
  14. Mąka Ł, Maćkiw E, Stasiak M, Wołkowicz T, Kowalska J, Postupolski J, Popowska M. (2018) Ciprofloxacin and nalidixic acid resistance of Salmonella spp. isolated from retail food in Poland. Int J Food Microbiol. 276:1-4. doi: 1016/j.ijfoodmicro.2018.03.012
  15. Piotrowska M, Przygodzińska D, Matyjewicz K, Popowska M. (2017) Occurrence and Variety of β-Lactamase Genes among Aeromonas spp. Isolated from Urban Wastewater Treatment Plant. Front Microbiol 8:863. doi: 3389/fmicb.2017.00863

RELATED BOOKS AND CHAPTERS:

  1. Markiewicz Z, Korsak D, Popowska M. (2021) Antybiotyki w dobie narastającej lekooporności. PWN, PZWL
  2. Krzemiński P, Markiewicz Z, Popowska M. Entry Routes of Antibiotics and Antimicrobial Resistance in the Environment. In Antibiotics and Antimicrobial Resistance Genes. Springer.
  3. Krzemiński P, Popowska M. (2020) Treatment Technologies for Removal of Antibiotics, Antibiotic Resistance Bacteria and Antibiotic-Resistant Genes, p. 415-434. In Antibiotics and Antimicrobial Resistance Genes. Springer.
  4. Markiewicz Z, Popowska M. (2020) Fate of Antibiotics and AMR/ARGs in the Environment. In Antibiotics and Antimicrobial Resistance Genes. Springer.
  5. Zalewska M, Popowska M. (2020) Antimicrobial/Antibiotic Resistance Genes Due to Manure and Agricultural Waste Applications. In Antibiotics and Antimicrobial Resistance Genes. Springer.
  6. Cytryn E, Markiewicz Z, Popowska M. (2017) Antibiotics and Antibiotics Resistance Genes Dissemination in Soils. In Soil Biology. Springer.

RELATED PROJECTS:

  1. INART- Intervention of antimicrobial resistance transfer into the food chain – Unisono-JPIAMR grant, National Science Centre (NCN), 2018-2022, PI: M. Popowska
  2. ANTIVERSA – Biodiversity as an ecological barrier for the spread of clinically relevant antibiotic resistance in the environment – Unisono-BiodivERsA grant, National Science Centre (NCN), 2020-2023, PI: M. Popowska